Evaluation of homeopathy effects associated with conventional periodontal therapy in randomized treatment of diabetic and non-diabetic patients with periodontitis

Periodontitis and Diabetes Mellitus type 2 (DMII) are chronic diseases treated by conventional practices and traditional medicine. In many cases, when conventional medicine cannot offer a satisfactory treatment, increases the demand for alternative therapies in chronic conditions. The aim of this study randomized was to compare and evaluate for one year clinical and serologic parameters the effects of homeopathy as an adjunct of conventional periodontal therapy in individual with periodontitis and DMII. Materials and Methods:85 individuals, of both genders, between 35 and 70 years old, participated in this randomized study, which 70 were eligible in Institute of Endocrinology and Diabetes of Rio de Janeiro-Brazil. They were divided into two groups G-1: individuals with periodontitis without systemic conditions and G-2: individuals with periodontitis and DMII. Both groups received homeopathic treatment and were evaluated in clinical and laboratorial examinations. The medication used was chosen based on the similarity principle, following the Berberis 6CH protocol (2 tablets, 2 times a day for 45 days), Mercurius Solubilis / Belladona / Hepar Sulfur-6CH (2 tablets, 3 times a day for 15 days) and a Pyrogenium 200CH biotherapeutic (single weekly dose, 2 weeks). Medications are prescribed in diluted low concentration doses for all signs and symptoms, while biotherapy is used for chronic stimulation Results:Both groups showed significant improvements throughout the study,clinical and laboratorial, at 1 year baseline: reductions in total cholesterol, triglycerides, glucose, glycated hemoglobin, uric acid and CPR. Statistical and descriptive analyzes were performed. The data obtained after laboratory analysis were tabulated and then submitted to the SPSS 17.0 software for Windows (SPSS Inc., Chicago, IL) and significance level with p <0.05. For most of parameters, G-1 performed better than G-2 (p<0.05).Conclusion:After 1 year follow-up this clinical trial suggest that homeopathy therapy, as an adjunct of periondontal treatment, improves local and systemic parameters and can provide better health condition.

Homeopathy and periodontal treatment in type ii diabetic patients: a 1-year randomized clinical trial

Abstract Chronic periodontitis (CP) and Diabetes mellitus type 2 (DMII) are chronic diseases usually treated by conventional practices. On the other hand, homeopathy can help to treat many different diseases. The aim of this study was to evaluate the effects of homeopathy (H) as an adjunct for non-surgical periodontal therapy (NSPT) in individuals with DMII and CP. Eighty individuals with CP and DM II, of both sexes and aged between 32 and 70 years, participated in this randomized, double-blind, placebo-controlled study. They were divided into two groups: control group (CG) and the test group (TG), and both groups received the NSPT. TG also received homeopathic therapy, including Berberis, Mercurius solubilis/Belladonna/Hepar sulphur and Pyrogenium, while CG received placebo. Clinical and laboratorial examinations were evaluated at baseline and after 1, 6 and 12 months of treatment. Both groups showed significant improvement throughout the study, for most of the parameters studied, but TG presented significative gain of CAL at 1 and 12 months compared to CG. Mean glucose and glycated hemoglobin significantly decreased in both groups after 6 and 12 months. However, there was a significantly further reduction of these parameters in TG, as compared to CG. In conclusion, homeopathy as supplement of NSPT may further improve health condition, including glycemic control, in DMII patients with CP.

Resumo Periodontite crônica (CP) e Diabetes mellitus tipo 2 (DMII) são doenças crônicas normalmente tratadas por práticas convencionais. Por outro lado, a homeopatia pode colaborar no tratamento de diferentes doenças. O objetivo do presente estudo foi avaliar os efeito da homeopatia como adjunto a terapia periodontal não cirúrgica (NSPT) em indivíduos com CP e DMII. Oitenta indivíduos com CP e DMII de ambos os sexos com idade entre 32 e 70 anos, participaram desse estudo clínico randomizado, placebo controlado, duplo cego. Os pacientes foram divididos em 2 grupos: grupo controle (CG) e grupo teste (TG), e ambos receberam NSPT. TG também recebeu terapia homeopática, incluindo Berberis, Mercurius solubilis/Belladonna/Hepar sulphur and Pyrogenium, enquanto o CG recebeu placebo. Exames clínicos e laboratoriais foram avaliados no baseline e 1, 6 e 12 meses após o tratamento. Ambos grupos mostraram melhoras significantes através do estudo para a maioria dos parâmetros avaliados. TG apresentou um ganho significativo nos níveis clínicos de inserção aos 1 e 12 meses, quando comparado ao grupo controle. Valores médios de glicemia e hemoglobina glicada reduziram significativamente em ambos grupos aos 6 e 12 meses. Entretanto, houve uma redução adicional desses parâmetros no TG, quando comparado ao CG. Concluindo, homeopatia como suplemento a NSPT pode promover as condições de saúde, incluindo o controle glicêmico, em pacientes com DMII e CP.

Efeitos da homeopatia no tratamento da Periodontite Crônica Generalizada em pacientes diabéticos tipo II: ensaio clínico randomizado, duplo-cego, placebo-controlado, com um ano de acompanhamento / Effect of homeopathy in the treatment of generalized chronic periodontitis in type 2 diabetic patients: randomized, double-blind, placebo-controlled, with a year of acompanhamentthe

Introdução e objetivo: a periodontite crônica (PC) é uma doença inflamatória crônica resultante do rompimento da homeostase entre microbiota subgengival e as defesas do hospedeiro. Como a homeopatia (H) visa restabelecer o equilíbrio da energia vital do paciente permitindo o movimento de cura do organismo. O objetivo do presente estudo foi avaliar os efeitos longitudinais (um ano) da terapia homeopática como coadjuvante no tratamento da periodontite crônica generalizada (PC) em pacientes diabéticos tipo II, sobre os parâmetros clínicos e laboratoriais, e seu impacto na qualidade de vida do paciente. Materiais e métodos: Oitenta pacientes com PC e DM II, de ambos os sexos e com idades entre 32 e 70 anos de idade, participaram desse ensaio clínico randomizado, duplo-cego, placebo-controlado. Os pacientes foram divididos em dois grupos: grupo controle (GC) e o Grupo teste (GT). Ambos os grupos receberam a Terapia periodontal básica (TPB). G-T recebeu adicionalmente a Terapia homeopática (TH): Berberis, Mercurius solubilis/ Belladona/ Hepar sulphur e Pyrogenium, enquanto GC recebeu placebo. As avaliações foram feitas no baseline e após 30 dias, 6 e 12 meses de tratamento. As respostas locais e sistêmicas foram avaliadas por parâmetros clínicos e laboratoriais respectivamente. Também, foi utilizado um questionário de qualidade de vida, Oral Health Impact Profile-14 (OHIP-14). Os dados foram analisados pelos testes paramétricos e não paramétricos. O nível de significância foi de 5%. Resultados: A avaliação intragrupos mostrou melhoras significativas em ambos os grupos, ao longo do estudo, para os parâmetros clínicos periodontais estudados. Na análise laboratorial, G-T mostrou níveis estatisticamente menores de LDL, Colesterol Total, Glicemia, Hemoglobina glicada e ácido úrico após 1ano de acompanhamento. Em relação ao impacto na qualidade de vida, G-T apresentou valores significativamente menores nos domínios limitação funcional, aos seis meses e dor física, aos seis meses. Conclusão: ambos os grupos apresentaram melhoras clínicas periodontais significativas durante o acompanhamento de um ano, No entanto, os resultados sugerem que os medicamentos homeopáticos, como coadjuvante para TPB, podem proporcionar melhoras em parâmetros laboratoriais e qualidade de vida para o tratamento convencional da PC.

Introduction and objective: the chronic periodontitis (CP) is a chronic inflammatory disease that results from the disruption of homeostasis between Subgingival microbiota and host defenses. As Homeopathy (H) aims to restore the balance of the vital energy of the patient allowing the healing movement of the body, the aim of this study was to evaluate the effects of H as a supporting role for basic periodontal therapy (BTP) in individuals with Diabetes mellitus type 2 (DMII).Materials and methods: After the calculation of sample size, 80 individuals with CP and DM II, of both sexes and aged between 32 and 70 years of age, participated in this randomized, double-blind, placebo-controlled. The patients were divided into two groups: control group (GC) and the test group (GT) both groups received the TPB. G-T received Additionally the homeopathic Therapy (TH): Berberis, Mercurius solubilis/Belladonna/Hepar sulphur and Pyrogenium, while GC received placebo. The evaluations were made at baseline and after 30 days, six and 12 months of treatment. The local and systemic responses were evaluated by clinical and laboratory parameters respectively. Also, it was used a questionnaire of quality of life, Oral Health Impact Profile-14 (OHIP-14). Data were analyzed by parametric and nonparametric tests. The significance level was 5%. Results: Intra-group evaluation showed significant improvement in both groups, throughout the study, for most of the parameters studied. G-T and G-C, in three evaluation periods (1, 6 and 12 months), most biofilm (BTI) and lower values of PBS were verified in G-C above the G-T, although similar levels of bleeding have been observed in the same periods; It was observed a value significantly lower NIC in G-T only to 30 days; in laboratory testing, G-T showed statistically lower levels of various parameters, namely: LDL, Total cholesterol and Glucose, glycated Hemoglobin and uric acid after 12 months. In relation to the impact on quality of life, G-T presented significantly lower values in functional domains and physical pain, to six months after BPT Conclusion: both groups showed significant improvement during the follow-up of one year However, the results of the present study suggest that homeopathy as supplement of BTP may improve some laboratory parameters and the quality of life of PC.